@HG Aha! Okay — looking back at the original post, a bit of reading miscomprehension on my part. A "my grandma" archetype, not a specific "my grandma". :)
In that case, a few pointers! macOS/Windows specific; I'm not terribly familiar with Android/ChromeOS, though there should be similar things on those platforms.
A good starting point on any platform is to start poking around at the accessibility settings (in macOS/iOS, System Settings > Accessibility; in Windows, Settings > Accessibility).
macOS:
https://support.apple.com/accessibility?cid=general-accessibility-marcom-08152025
Windows:
https://www.microsoft.com/en-us/windows/learning-center/how-to-find-computer-accessibility-settings
For people just starting to lose vision, zoom/magnification features are a good starting point. For some, this may be all they need; for those with degenerative conditions who can expect their vision to deteriorate over time, it may be helpful to use zoom/magnification features as they get used to read-aloud and/or screen reader functionality.
Most (maybe even all) platforms have some form of read-aloud feature, which may be enough for some people. On the Mac, Accessibility Reader and Speak Selection are often quick ways to start reading specific things without going for a full screen reader experience.
If a person is an ebook reader, many ebook apps have their own built-in read-aloud capability. My usual recommendation is the cross-platform Thorium:
https://thorium.edrlab.org/en/
For those whose vision is deteriorating or has deteriorated enough that a screen reader is the way to go, I usually recommend NVDA by
@NVAccess for Windows (because it's free and good); VoiceOver is the only option for macOS. Both will be a somewhat steep learning curve, and the first thing I recommend to anyone getting started is to begin by learning what the "shut up" button is. :) Because screen readers read _everything_ that's going on, they can be overwhelming when you're getting used to them. Deque has good one-sheet quick reference guides to the major commands for the most common screen readers:
https://dequeuniversity.com/screenreaders/
Specifically for macOS users, the AppleVis website has great resources for getting started:
https://www.applevis.com
You may want to reach out to your local National Federation of the Blind chapter to see if they have pointers to local resources:
https://ak.nfb.org
Hopefully these help!
