In Germany we don't say:
"What's wrong with you?"
We say...
Hast du Lack gesoffen?
(Did you drink paint?)
Hat dir jemand ins Gehirn geschissen?
(Did someone shit into your brain?)
Hast du noch alle Latten am Zaun?
(Do you still have all your planks on the fence?)
Brennt's bei dir?
(Is it burning at your place?)
Bei dir piepts wohl?
(Is it chirping at your place?)
Hast du einen an der Waffel?
(Do you have one at the waffle?)
You're welcome.