Replying to
@mhoye@cosocial.ca FWLIW, as a practical example, a few years back I used an old Lacie 1U enclosure to make a boot drive for a FreeBSD BackupPC server. Inside the enclosure I put a power strip, a USB hub, and 4 USB enclosures for 2.5" drives. I put boot code on each drive, then made a 4-way mirror using a ZFS partition on each drive. As expected, several of the drives failed over time, but it was easy to replace a dead drive with a 'new' one - just partition the new drive, put the boot code on, and replace the device in the zpool.