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bioRxiv

@biorxivpreprint@biologists.social
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Joined August 18, 2023
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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

Longitudinal blood DNA methylation profiling reveals disrupted immune-epigenetic adaptation and candidate stress related loci in postpartum depression https://www.biorxiv.org/content/10.64898/2026.04.03.716376v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

Dispersal rate limits range expansion rate only when it is slower than climate velocity https://www.biorxiv.org/content/10.64898/2026.03.16.712231v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

A peripherally restricted cannabinoid 1 receptor agonist provides analgesic benefit from neuropathic pain and a lack of addiction-related behavior https://www.biorxiv.org/content/10.64898/2026.04.13.718281v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Energetic misfires: Hybridization drives transgressive expression in metabolic pathways in thermally divergent Icelandic stickleback https://www.biorxiv.org/content/10.64898/2026.04.17.719192v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Can coastal plantation forests substitute for natural coastal forests as bird and plant habitat? A test across coastal zonation https://www.biorxiv.org/content/10.64898/2026.04.16.718952v1?med=mas

Can coastal plantation forests substitute for natural coastal forests as bird and plant habitat? A test across coastal zonation
bioRxiv

Can coastal plantation forests substitute for natural coastal forests as bird and plant habitat? A test across coastal zonation

Natural forests are increasingly being replaced by plantation forests, highlighting an urgent need to reconcile forest use and biodiversity conservation. Coastal forests serve as refugia for species of conservation concern, but they have been globally replaced by plantations, and conversion remains ongoing. As natural coastal forests become increasingly scarce, opportunities for direct biodiversity comparisons with coastal plantations are also disappearing. This scarcity leads to underestimation

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Climate gradients drive the evolution of seed morphology and life history with impacts to seedling fitness in Fraxinus nigra https://www.biorxiv.org/content/10.64898/2026.04.17.719241v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Hydroperiod buffers water surface decline in dryland wetlands: A 36-year analysis in Hwange National Park https://www.biorxiv.org/content/10.64898/2026.04.13.718152v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Gradient-specified optimization based on muscle surface mesh and moment arm as an effect-oriented approach of automated musculotendon path modeling https://www.biorxiv.org/content/10.64898/2026.04.15.718668v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

A hierarchy of locomotion costs shapes optimal foraging strategy https://www.biorxiv.org/content/10.64898/2026.04.14.718484v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

EBV Triggers a Distinct Antiviral Response in HMC3 Cells https://www.biorxiv.org/content/10.64898/2026.04.03.716358v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy https://www.biorxiv.org/content/10.64898/2026.04.17.719285v1?med=mas

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy
bioRxiv

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy

Cerebral amyloid angiopathy (CAA), a major vascular contributor to cognitive decline, is present in 85–95% of Alzheimer’s disease (AD) patients. Despite its high prevalence, the mechanisms by which CAA contributes to neurodegeneration remain poorly understood. Triggering receptor expressed on myeloid cells 2 (TREM2), an innate immune receptor expressed exclusively by microglia, regulates activation, phagocytosis, and amyloid clearance, thereby shaping neuroinflammation. Loss-of-function mutation

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

TBX5 dosage governs ventricular cardiomyocyte maturation, specialization and dedifferentiation in vivo https://www.biorxiv.org/content/10.64898/2026.04.13.718086v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers https://www.biorxiv.org/content/10.64898/2026.04.14.718476v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat https://www.biorxiv.org/content/10.64898/2026.04.17.719234v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

TRACE: End-to-end temporal inference and annotation of animal behaviors from video https://www.biorxiv.org/content/10.64898/2026.04.14.718392v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Chemical Genetic Screen Identifies PSD3 as a Direct Substrate of NUAK1 that Regulates Dendritic Spine Maturation https://www.biorxiv.org/content/10.64898/2026.04.16.718295v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Assessing the impact of artificial night lighting regulations designed to protect astronomical observatories on seabirds and bats https://www.biorxiv.org/content/10.64898/2026.04.16.718868v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

The BraALA3 Homologs Mediate Propiconazole-Modulated Plant Growth in flowering Chinese cabbage https://www.biorxiv.org/content/10.64898/2026.04.16.718850v1?med=mas

The BraALA3 Homologs Mediate Propiconazole-Modulated Plant Growth in flowering Chinese cabbage
bioRxiv

The BraALA3 Homologs Mediate Propiconazole-Modulated Plant Growth in flowering Chinese cabbage

In agriculture, propiconazole (PCZ) controls excessive growth in flowering Chinese cabbage but poses dietary safety risks due to residue accumulation. Therefore, identifying novel PCZ targets and breeding PCZ-free cultivars is critical for the safe production of flowering Chinese cabbage. Here, we identified three P4-ATPase flippase homologs aminophospholipid ATPase 3 (BraALA3a/b/c) in flowering Chinese cabbage that function as sensitive targets for PCZ. These proteins exhibit high binding affin

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Hybrid virtual reality object lifting matches real-world object lifting https://www.biorxiv.org/content/10.64898/2026.04.13.718283v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

Protection of algae grown for biofuel using a consortium of environmentally harvested bacteria https://www.biorxiv.org/content/10.64898/2026.03.18.712687v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Inclusive Biology Curriculum Interventions Can Reduce High School Students' Bioessentialist Beliefs https://www.biorxiv.org/content/10.64898/2026.04.16.719004v1?med=mas

Inclusive Biology Curriculum Interventions Can Reduce High School Students’ Bioessentialist Beliefs
bioRxiv

Inclusive Biology Curriculum Interventions Can Reduce High School Students’ Bioessentialist Beliefs

Lesbian, gay, bisexual, transgender, queer, intersex, and asexual (LGBTQIA+) students continue to face violence, exclusion, and barriers at school, including in STEM education. A key underexamined factor in diversity, equity, and inclusion (DEI) efforts is the content of the life science curriculum, which is uniquely positioned to reinforce or refute bioessentialist, binary, and heteronormative biases. Outdated science curricula not only conflict with current scientific evidence but can also per

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Adaptation to free-living drives loss of beneficial endosymbiosis through metabolic trade-offs https://www.biorxiv.org/content/10.64898/2026.04.16.718893v1?med=mas

Adaptation to free-living drives loss of beneficial endosymbiosis through metabolic trade-offs
bioRxiv

Adaptation to free-living drives loss of beneficial endosymbiosis through metabolic trade-offs

Symbioses are widespread ([1][1]) and underpin the function of diverse ecosystems ([2][2]–[6][3]), but their evolutionary stability is challenging to explain ([7][4],[8][5]). Fitness trade-offs between contrasting intracellular and extracellular niches could act to stabilise endosymbioses because adaptation to either niche is predicted to reduce fitness in the alternate niche, thus reinforcing symbiosis ([8][5],[9][6]). Here, we experimentally evolved four diverse Chlorella green algal endosymbi

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

A collicular-hypothalamic pathway for social visual awareness https://www.biorxiv.org/content/10.64898/2026.04.17.719268v1?med=mas

A collicular–hypothalamic pathway for social visual awareness
bioRxiv

A collicular–hypothalamic pathway for social visual awareness

Awareness of other individuals is a foundational element of social behavior. Here we examined how specific neural systems detect and signal the visual presence of conspecifics related to social arousal and motivation. We found that visual exposure to videos of other mice can activate hypothalamic oxytocin neurons and promote onset of pup retrieval behavior in naive virgin female mice. A range of social videos depicting conspecifics in diverse contexts, including but not limited to parental behav

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

Infauna selectively enhance DNA virus diversity and activity in marine sediments https://www.biorxiv.org/content/10.64898/2026.03.17.711404v1?med=mas

Infauna selectively enhance DNA virus diversity and activity in marine sediments
bioRxiv

Infauna selectively enhance DNA virus diversity and activity in marine sediments

Viruses regulate microbial mortality and biogeochemical cycling in marine sediments; however, the ecological drivers of sediment viral communities remain unclear. Infauna, including sediment-dwelling meiofauna and macrofauna, are major ecosystem engineers that reshape sediment structures and microbial processes, but their influence on viruses is unknown. We combined infaunal gradient incubations with metagenomic and metatranscriptomic analyses to assess viral DNA and RNA responses. DNA viruses s

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Antimicrobial Resistance Profiling and Phenotypic Characterization of Archived Clinical Bacillus paranthracis Strains https://www.biorxiv.org/content/10.64898/2026.04.16.719033v1?med=mas

Antimicrobial Resistance Profiling and Phenotypic Characterization of Archived Clinical Bacillus paranthracis Strains
bioRxiv

Antimicrobial Resistance Profiling and Phenotypic Characterization of Archived Clinical Bacillus paranthracis Strains

Bacillus paranthracis was formally defined as a species in 2017, after decades of carrying the name “emetic B. cereus” based on cereulide production and clustering within B. cereus sensu lato phylogenetic group III. Commonly associated with foodborne intoxication, reports rarely link B. paranthracis to non-foodborne clinical illness. As such, the new taxonomy and close resemblance of the name to the biothreat pathogen Bacillus anthracis cause confusion in diagnostic and public health settings. T

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

DOME Copilot: Making transparency and reproducibility for artificial intelligence methods simple https://www.biorxiv.org/content/10.64898/2026.04.16.718888v1?med=mas

DOME Copilot: Making transparency and reproducibility for artificial intelligence methods simple
bioRxiv

DOME Copilot: Making transparency and reproducibility for artificial intelligence methods simple

Unprecedented breakthroughs are being made in life science research through the application of artificial intelligence (AI). However, adherence to method reporting guidelines is necessary to support their reusability and reproducibility. The DOME Copilot solution extracts structured reports of AI methods using a large language model to help interpret manuscripts. It is a fast and efficient resource capable of scaling to annotate the corpus of global AI literature, unlocking value and trust in pu

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

sigNATURE maps cohort-specific T-cell states to reproducible programs of ICI response https://www.biorxiv.org/content/10.64898/2026.04.14.718532v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Expectation triggers a change-like EEG response without acoustic change https://www.biorxiv.org/content/10.64898/2026.04.13.718093v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

High-efficiency, site-specific integration of kilobase-scale DNA into plant genomic safe harbors via PrimeStack editors https://www.biorxiv.org/content/10.64898/2026.04.13.718181v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Distinct Control States Underlie Voluntary Task Switching: Evidence for Capacity-Dependent Control Modes https://www.biorxiv.org/content/10.64898/2026.04.12.716959v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Highly replicable multisite patterns of adolescent white matter maturation https://www.biorxiv.org/content/10.64898/2026.04.18.719321v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Cell fusion reprograms tumor cells and promotes RUNX1-mediated invasion and dissemination in colorectal cancer https://www.biorxiv.org/content/10.64898/2026.04.12.717781v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

Large-scale recovery of integron cassettes for gene discovery screens https://www.biorxiv.org/content/10.64898/2026.03.17.712381v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Effect of Jasmonic Acid on Chlorophyll Content in Wheat (Triticum aestivum L.) Plants Infested with Russian Wheat Aphid (Diuraphis noxia) https://www.biorxiv.org/content/10.64898/2026.04.16.718935v1?med=mas

Effect of Jasmonic Acid on Chlorophyll Content in Wheat (Triticum aestivum L.) Plants Infested with Russian Wheat Aphid (Diuraphis noxia)
bioRxiv

Effect of Jasmonic Acid on Chlorophyll Content in Wheat (Triticum aestivum L.) Plants Infested with Russian Wheat Aphid (Diuraphis noxia)

Russian wheat aphid ( Diuraphis noxia Homoptera; Aphididae) is a major pest that significantly reduces chlorophyll content and photosynthetic capacity in wheat ( Triticum aestivum L.), leading to substantial crop yield losses. Jasmonic acid (JA) is a plant signaling molecule known to activate defense mechanisms against herbivorous insects. This study examined the effectiveness of exogenous jasmonic acid application in maintaining chlorophyll content during Russian wheat aphid infestation. A pot

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

QUANTIFYING GLYCOGEN AND LIPID DROPLET SYNTHESIS IN OVARIAN AND CERVICAL CANCER CELLS USING DEUTERATED RAMAN PROBES WITH STIMULATED RAMAN SCATTERING MICROSCOPY https://www.biorxiv.org/content/10.64898/2026.03.16.712189v1?med=mas

QUANTIFYING GLYCOGEN AND LIPID DROPLET SYNTHESIS IN OVARIAN AND CERVICAL CANCER CELLS USING DEUTERATED RAMAN PROBES WITH STIMULATED RAMAN SCATTERING MICROSCOPY
bioRxiv

QUANTIFYING GLYCOGEN AND LIPID DROPLET SYNTHESIS IN OVARIAN AND CERVICAL CANCER CELLS USING DEUTERATED RAMAN PROBES WITH STIMULATED RAMAN SCATTERING MICROSCOPY

Epithelial ovarian cancer remains one of the most lethal malignancies among women, with late-stage diagnoses yielding 5-year survival rates below 30%. The metabolic heterogeneity of the tumor microenvironment (TME) highlights the need for methods capable of rapid, chemically specific phenotyping. Stimulated Raman scattering (SRS) microscopy when combined with deuterium labeled metabolites enables the non-invasive high contrast interrogation of cellular metabolic pathways. In this study, we used

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

An orthogonal near-infrared optical switch for wireless neuromodulation in freely behaving mice https://www.biorxiv.org/content/10.64898/2026.04.12.717984v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Loss of enteric BDNF TrkB signaling and VIPergic dysfunction underlie gastrointestinal dysmotility in a Mecp2-null mouse model of Rett syndrome https://www.biorxiv.org/content/10.64898/2026.04.12.718037v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Systemic injection of metabotropic glutamate 2/3 receptor antagonist LY341495 disrupts reward-related behaviors in mice. https://www.biorxiv.org/content/10.64898/2026.04.18.719355v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

CETP alternative splicing variation impacts human traits https://www.biorxiv.org/content/10.64898/2026.03.16.712143v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Frontal Brain Injury Reduces Sensitivity to Reward-Predictive Cues and Remodels the Nucleus Accumbens https://www.biorxiv.org/content/10.64898/2026.04.17.718474v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Drought disrupts volatile-mediated predator foraging and oviposition, weakening trait-mediated top-down control https://www.biorxiv.org/content/10.64898/2026.04.16.718996v1?med=mas

Drought disrupts volatile-mediated predator foraging and oviposition, weakening trait-mediated top-down control
bioRxiv

Drought disrupts volatile-mediated predator foraging and oviposition, weakening trait-mediated top-down control

1. Drought is a major abiotic stressor that can restructure trophic interactions by limiting herbivore success and disrupting chemical signaling between plants and natural enemies. In tritrophic systems, plant volatiles guide natural enemy foraging and reproductive investment, often scaling with herbivore density; however, it is unclear whether drought alters this relationship and weakens top-down control. 2. Using a tomato-aphid-ladybeetle system, we tested how drought and herbivore density

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Organization of functional brain networks architecture during negative movie watching in late adulthood https://www.biorxiv.org/content/10.64898/2026.04.13.717690v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Comprehensive profiling reveals Sialyl-Tn upregulation and prognostic value in prostate cancer https://www.biorxiv.org/content/10.64898/2026.04.14.718221v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

Loss of Mycobacterium marinum ESX-1 genes increase transcription of ESX-6 genes https://www.biorxiv.org/content/10.64898/2026.03.18.712377v1?med=mas

Loss of Mycobacterium marinum ESX-1 genes increase transcription of ESX-6 genes
bioRxiv

Loss of Mycobacterium marinum ESX-1 genes increase transcription of ESX-6 genes

Mycobacteria form rough and smooth colonies. The Mycobacterium marinum strain 1218S is a smooth colony forming variant isolated from the 1218R strain, which forms rough colonies and is more virulent than 1218S in infecting fish. Genes for the type VII secretion ESX-1 system, which includes mycobacterial virulence genes, have been partially duplicated in M. marinum and is refered to as ESX-6. We recently reported that several ESX-1 genes are missing in the 1218S strain. On the basis of the comple

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Novel cell and tissue dynamics drive the unusual biology of the catch tentacle, an inducible organ of aggression found in the sea anemone Metridium senile https://www.biorxiv.org/content/10.64898/2026.04.13.718255v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Relating layer fMRI signals to acoustics and intracranial neuronal activity in the human auditory cortex in a naturalistic design https://www.biorxiv.org/content/10.64898/2026.04.15.718614v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Astrocytes mediate the pro-cognitive value of α7nAChRs and of α7nAChR-targeting therapeutics https://www.biorxiv.org/content/10.64898/2026.04.16.719027v1?med=mas

Astrocytes mediate the pro-cognitive value of α7nAChRs and of α7nAChR-targeting therapeutics
bioRxiv

Astrocytes mediate the pro-cognitive value of α7nAChRs and of α7nAChR-targeting therapeutics

The α7-nicotinic acetylcholine receptor (α7nAChR) has driven extensive research over the past three decades for its pro-cognitive potential. It is the leading druggable target for the cognitive deficits associated with schizophrenia and has motivated major pharmaceutical and clinical efforts to ameliorate similar impairments in other neurological disorders, such as Alzheimer’s disease (AD). Yet, a systematic evaluation of the role played by α7nAChR in cognition, and its mechanistic underpinnings

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

Cannabidiol rescues age-associated cognitive decline in mouse model https://www.biorxiv.org/content/10.64898/2026.04.12.711942v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 5mo ago

A scalable hippocampal code for flexible interval timing through persistent activity https://www.biorxiv.org/content/10.64898/2026.04.12.716593v1?med=mas

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bioRxiv @biorxivpreprint@biologists.social
· 6mo ago

Taxonomic filtering accompanies functional expansion during long-term soil restoration https://www.biorxiv.org/content/10.64898/2026.03.17.712278v1?med=mas

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