StructBiolCommunications

This structure of a tRNA acceptor-stem mimic demonstrates the use of bromine and phosphorus anomalous scattering for RNA structure determination #Crystallography #AnomalousScattering #NucleicAcids https://doi.org/10.1107/S2053230X26000658

New issue is out! https://journals.iucr.org/f/issues/2026/05/00/

On the cover: the atomic structure of human dystrophin spectrin-like repeat 24 determined at 2.14 Å resolution https://journals.iucr.org/f/issues/2026/05/00/rl5207/index.html

Modifying the bacterial strain led to cleaner bacterial expression of a synthetic BRIL antibody that facilitates protein structure determination via both crystallography and cryo-EM #CryoEM #XRayCrystallography #BRIL https://doi.org/10.1107/S2053230X26001548

High-resolution structures of α-bCA2 with sulfonamide derivatives provides experimentally supported information defining their binding mode and supporting inhibitor optimization #CarbonicAnhydraseII #SulfonamideInhibitors #XRayCrystallography https://doi.org/10.1107/S2053230X26002128

An acylated GLP-1/GIP analogue peptide forms a uniquely porous spiral crystal structure composed of clockwise-ascending monomers in a square pattern #GLP1 #Peptides #Crystallization https://doi.org/10.1107/S2053230X26001937

A comprehensive survey catalogues all pentatricopeptide repeat protein crystal structures, analysing their crystallographic properties, structural features and contributions to understanding function #PentatricopeptideRepeatProteins #RNARecognition https://doi.org/10.1107/S2053230X26002311

Our April issue is out now! https://journals.iucr.org/f/issues/2026/04/00/

Crystallization was investigated as a preparative strategy for a GLP-1/GIP lipopeptide and led to what is believed to be the first reported crystal structure of an unbound GLP-1/GIP analogue https://doi.org/10.1107/S2053230X26001937

The structure of endo-β-N-acetylglucosaminidase was determined at 1.8 Å resolution, revealing a unique spatial arrangement of domain IV, which is suggested to contribute to substrate recognition #EndoNAcetylglucosaminidases #GH85 #ComplexNGlycans https://doi.org/10.1107/S2053230X26001214

The structure of a chimeric efflux pump was determined by cryoEM under apo and kanamycin-supplemented conditions and adopted symmetric-like and asymmetric conformations #PseudomonasAeruginosa #DrugEffluxTransporters #MembraneProteins https://doi.org/10.1107/S2053230X26001202

MBP fusion is an effective and generalizable approach to enable crystallographic studies of engineered binding proteins that are otherwise difficult to crystallize #Monobody #Aggregation #MaltoseBindingProtein https://doi.org/10.1107/S2053230X26000798

This report of the structure of a carbon-nitrogen hydrolase https://doi.org/10.1107/S2053230X26001330 is the first contribution to the Early Career Scientists in Structural Science special issue! Find out more, join in and submit at https://journals.iucr.org/early-career/special-issue-2026.html

Here's our March issue: https://journals.iucr.org/f/issues/2026/03/00/

On the cover: the structure of the chimeric RND-type multidrug-efflux pump protein MexBYB was determined by cryoEM under apo and kanamycin-supplemented conditions https://journals.iucr.org/f/issues/2026/03/00/ek5041/index.html

Sample preparation from α- and β-crustacyanin pigments purified from ex vivo material from the American lobster Homarus americanus for X-ray crystallography and cryo-electron microscopy studies #Astaxanthin #Crustacyanin #Absorption https://doi.org/10.1107/S2053230X2600018X

The highest resolution DNA-free TaXPD structure to date uniquely resolves loop 510–514 in the long-form, DNA-free TaXPD model #Helicases #Archaea https://doi.org/10.1107/S2053230X26000105

Potential 14-3-3 binding sites in sirtuins were identfied and the interactions of peptides representing phosphorylation sites in sirtuin 3 and sirtuin 1 with 14-3-3 proteins were characterized #Sirtuin #Phosphopeptides #Regulation https://doi.org/10.1107/S2053230X25010908

The flexible loop in Methanococcus jannaschii dihydroorotase with substrate bound adopts both the loop-out and loop-in conformations #Dihydroorotase #MethanococcusJannaschii #PyrimidineBiosynthesis https://doi.org/10.1107/S2053230X25010556

The crystal structure of the class IIIb chitinase from Crocus vernus is reported, together with in silico analyses of inhibitor interactions and antifungal and chitinase assays #CrocusVernus #Chitinase #TIM https://doi.org/10.1107/S2053230X25009720

Single surface substitutions can mprove the crystallizability and diffraction properties of a flexible two-domain protein even if they increase the entropy of the residue #MultidomainProtein #PointMutation #ProteinCrystallization https://doi.org/10.1107/S2053230X25010416

What are the effects of the presence of polyethylene glycol in macromolecular crystals? #PolyethyleneGlycol #Mechanism #Crystallization https://doi.org/10.1107/S2053230X2501043X

February issue now available: https://journals.iucr.org/f/issues/2026/02/00/

The cover shows the crystal structure of an RNA complex composed of four strands determined by the complementary use of bromine and phosphorus anomalous signals. Find out more at https://doi.org/10.1107/S2053230X26000658